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Volume 22 , Issue 3
May/June 2007

Pages 417422


Platelet-Enriched Fibrin Glue and Platelet-rich Plasma in the Repair of Bone Defects Adjacent to Titanium Dental Implants

Tae-Min You, DDS / Byung-Ho Choi, DDS, PhD / Shi-Jiang Zhu, MD / Jae-Hyung Jung, DDS / Seoung-Ho Lee, DDS, PhD / Jin-Young Huh, DDS / Hyun-Jung Lee, DDS / Jingxu Li, DDS


PMID: 17622008

Purpose: The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants. Materials and Methods: In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group). Results: After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P < .05). Discussion and Conclusion: Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants. Int J Oral Maxillofac Implants 2007;22:417422

Key words: bone grafting, bone regeneration, dental implants, fibrin glue, platelet-rich plasma


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