LOGIN
 
Share Page:
Back

Volume 21 , Issue 4
July/August 2006

Pages 543–550


Correlations Between Clinical Parameters and Interleukin-6 and Interleukin-10 Levels in Saliva from Totally Edentulous Patients with Peri-implant Disease

Stanislav Liskmann, MD, DDS / Tiiu Vihalemm, Dr Med / Olev Salum, MD, DDS, PhD / Kersti Zilmer, Dr Med / Krista Fischer, PhD / Mihkel Zilmer, MD, PhD


PMID: 16955604

Purpose: The purpose of the present study was (1) to assess the relationship between clinical parameters and concentrations of the proinflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10 in the saliva of totally edentulous patients with implant-supported overdentures; (2) to assess whether estimation of IL-6 and IL-10 levels in saliva could be a useful laboratory tool to detect changes preceding serious clinical complications. Materials and Methods: Thirty healthy adult volunteers (14 men and 16 women) with implant-supported overdentures were recruited from Tallinn Dental Clinic. The biochemical and clinical parameters evaluated were the levels of IL-6 and IL-10 in saliva, pocket probing depth (mm), Gingival Index (0,1, 2, or 3), and bleeding on probing (0 or 1). Results: The level of IL-6 in saliva in the peri-implant disease group was significantly elevated compared to the healthy group. IL-10 could be detected only in the saliva of patients with peri-implant disease, and it did not appear at detectable amounts in saliva of healthy controls. In addition, the levels of IL-6 and IL-10 in peri-implant disease group were positively correlated with clinical parameters. Conclusions: These data suggest that a significant relationship exists between the amount of a proinflammatory cytokine (IL-6) and the inflammatory response in peri-implant tissue. The results also suggest that IL-6 and IL-10 could be used as markers of peri-implant disease together and that the level of the latter cytokine gives additional information about the potency of an organism’s integrated immune response for maintenance of inflammatory balance. (More than 50 references) Int J Oral Maxillofac Implants 2006;21:543–550

Key words: dental implants, interleukin-6, interleukin-10, peri-implant disease, peri-implantitis, saliva


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help