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Volume 13 , Issue 5
September/October 1998

Pages 620-629

Wound Healing Around Endosseous Implants in Experimental Diabetes

Marc L. Nevins, DMD, MMSc, Nadeem Y. Karimbux, DMD, MMSc.

PMID: 9796145

Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes. (INT J ORAL MAXILLOFAC IMPLANTS 1998;13:620-629) Key words: dental implants, diabetes, osseointegration, wound healing

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