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Volume 30 , Issue 1
January/February 2015

Pages 216–222


Guided Bone Regeneration of Mandibles Using Chitosan Scaffold Seeded with Characterized Uncultured Omental Adipose–Derived Stromal Vascular Fraction: An Animal Study

Rahim Mohammadi, DVM, DVSc/Keyvan Amini, DVM, MSc, MVetSc


PMID: 25615927
DOI: 10.11607/jomi.3542

Purpose: The aim of this study was to assess the effect of characterized uncultured omental adipose–derived stromal vascular fraction (SVF) on bone regeneration in a circular mandibular bone defect. A chitosan scaffold was used to maintain the cells in situ. Materials and Methods: Seventy-five healthy male white Wistar rats were randomized into three experimental groups. In the control group, a surgical bone defect was created in the body of the mandible. In the scaffold group, a chitosan scaffold was placed into the defect. In the scaffold/SVF group, a scaffold was implanted and seeded with 10-μL SVF aliquots (2.19 ± 0.43 × 107 cells). Results: Microscopic and histomorphometric analyses showed improved and earlier regeneration of bone defects in the scaffold/SVF group compared to the scaffold-only group. Conclusion: In this animal model, the use of a chitosan scaffold with SVF aliquots resulted in significantly earlier regeneration of bone than the use of the scaffold alone.


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