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Volume 30 , Issue 1
January/February 2015

Pages 202207


Vertical Bone Augmentation Using Recombinant Bone Morphogenetic Protein, Mineralized Bone Allograft, and Titanium Mesh: A Retrospective Cone Beam Computed Tomography Study

Craig M. Misch, DDS, MDS/Ole T. Jensen, DDS, MS/Michael A. Pikos, DDS/Jay P. Malmquist, DMD


PMID: 25615925
DOI: 10.11607/jomi.3977

Purpose: This retrospective study evaluated the use of a composite graft of recombinant human bone morphogenetic protein-2 (rhBMP-2) and particulate mineralized bone allograft protected by a titanium mesh for vertical bone augmentation. Materials and Methods: A review of data on patients from four oral and maxillofacial surgery practices in the United States who required vertical augmentation prior to implant treatment was conducted. Vertical augmentation was accomplished with rhBMP-2 in an absorbable collagen sponge (ACS) carrier and particulate allograft. Cone beam computed tomography was used to measure vertical bone gains using this technique. Results: Sixteen vertical ridge augmentation procedures were performed in 15 patients. The maximum vertical bone gains ranged from 4.4 to 16.3 mm. The average maximum vertical bone gain was 8.53 mm. The procedure allowed implant placement in all patients. Forty implants were inserted into the grafted ridges after a minimum of 6 months of healing. All implants integrated and were used for prosthetic support. Conclusion: This study suggests that rhBMP-2/ACS and particulate mineralized bone allograft protected by a titanium mesh offers favorable vertical bone gains to allow dental implant placement.


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