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Volume 28 , Issue 6
November/December 2013

Pages e494–e502


Somatic Stem Cell Biology and Periodontal Regeneration


Bin Zhu, DDS, PhD/Yihan Liu, DDS, PhD/Dehua Li, DDS, PhD/Yan Jin, DDS, PhD


PMID: 24278958
DOI: 10.11607/jomi.te30

Somatic stem cells have been acknowledged for their ability to differentiate into multiple cell types and their capacity for self-renewal. Some mesenchymal stem cells play a dominant role in the repair and reconstruction of periodontal tissues. Both dental-derived and some non–dental-derived mesenchymal stem cells possess the capacity for periodontal regeneration under certain conditions with induced differentiation, proliferation, cellular secretion, and their interactions. Stem cell–based tissue engineering technology promises to bring improvements to periodontal regeneration, biologic tooth repair, and bioengineered implants. The present review discusses the roles and values of various somatic stem cells in periodontal regeneration.


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