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Volume 28 , Issue 5
September/October 2013

Pages e304e309


Biointegration of the Osteo-odonto Lamina in the Modified Osteo-odonto Keratoprosthesis: Engineering of Tissue to Restore Lost Vision


Yoh Sawatari, DDS/Robert E. Marx, DDS/Victor L. Perez, MD/Jean-Marie Parel, PhD


PMID: 24066348
DOI: 10.11607/jomi.te12

The modified osteo-odonto keratoprosthesis (MOOKP) is a biologic keratoprosthesis that is used to treat a severely scarred cornea. The procedure involves multiple stages, including the transplantation of buccal mucosa to the damaged ocular surface and the implantation of an osteo-odonto lamina with a mounted polymethylmethacrylate lens. Among the keratoprostheses currently available, the MOOKP has proven to be the most effective based on the number of patients who have undergone the procedure and the duration of documented follow-up. Upon successful biointegration of the osteo-odonto lamina, the keratoprosthesis is able to resist resorption, provide stability, and prevent bacterial invasion and epithelial ingrowth. The effectiveness of the MOOKP is dependent on the anatomic and physiologic characteristics of the dental tissues and periodontal ligament.


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