LOGIN
 
Share Page:
Back

Volume 28 , Issue 4
July/August 2013

Pages 1027–1036


Physicochemical, Pharmacologic, and in Vitro Cellular Effects of Loading Collagen Membranes with Zoledronic Acid

Jian Liao, DDS/YanHua Meng, DDS/JunJiang Zhai, DDS/Cai Wen, DDS/MinHua Ten, DDS/Ai Tian, DDS/Yong Wang, BDS/Xing Liang, DDS, PhD


PMID: 23869361
DOI: 10.11607/jomi.3030

Purpose: There is a need for improved methods of reducing peri-implant bone loss. This study evaluated the structural, drug loading, drug release, and in vitro characteristics of collagen membranes impregnated with zoledronic acid (ZA). Materials and Methods: Two commercially available collagen barrier membranes (Bio-Gide and BME-10X) were loaded with ZA. The physicochemical and pharmacologic properties of the membranes were characterized with scanning electron microscopy, energy dispersive spectroscopy, Fourier transform infrared spectroscopy, and high-performance liquid chromatography. The ZA-loaded membrane’s inhibition of osteoclasts and promotion of osteoblast growth was evaluated in vitro at ZA concentrations of 0, 10–4, 10–3, and 10–2 mol/L. Results: The disappearance of micropores between Bio-Gide collagen fibers and the formation of crystalloids on the surface of BME-10X membranes following ZA loading was evident under the microscope. Phosphorus was detected on the membranes, and amide shifts were observed. Greater amounts of ZA loading and slower ZA release were evident for Bio-Gide membranes. Osteoclast numbers were reduced with ZA, and a corresponding decrease in bone resorption was evident at higher ZA concentrations (P < .05). After 7 days, at a ZA concentration of 10–3 mol/L, Bio-Gide membranes had an increased osteoblast proliferation index, while both types of membranes displayed increased alkaline phosphatase expression. Conclusion: Collagen membranes loaded with ZA provided delayed drug release. This study may offer a novel therapeutic strategy for minimizing peri-implant bone resorption.


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help