LOGIN
 
Share Page:
Back

Volume 28 , Issue 2
March/April 2013

Pages 432–443


Use of a Perforated Scaffold-Retaining Abutment to Achieve Vertical Bone Regeneration Around Dental Implants in the Minipig

Sylvain Catros, DDS, PhD/Bo Wen, DMD, PhD/Peter Schleier, DDS/David Shafer, DMD/Michel Dard, DDS, PhD/Marcel Obrecht/Martin Freilich, DDS/Liisa Kuhn, PhD


PMID: 23527345
DOI: 10.11607/jomi.2782

Objective: To evaluate the effect of perforated scaffold retainers used in conjunction with dental implants and osteoinductive scaffolds to regenerate vertical supracrestal alveolar bone in an intraoral minipig model. Materials and Methods: Three months after extraction of mandibular premolars and first molars from six adult minipigs, two titanium (Ti) custom implants were placed bilaterally in the edentulous mandibles for a total of four implants per animal. The upper 2.5 mm of the implant was left above bone level and covered with: (1) wide-neck healing caps; (2) perforated, overhanging custom scaffold retainers (umbrellas); or (3) scaffold retainers and demineralized minipig bone allograft (DBM) and nonglycosylated bone morphogenetic protein 2 (ng/rhBMP-2)–treated implants. All constructs were submerged beneath soft tissue flaps for 8 weeks. Two dental implant surfaces were compared: SLA and SLActive. Samples were retrieved after 8 weeks and analyzed by radiography, micro–computed tomography and histomorphometry. Results: All implants were stable at the end of the experiment. Histomorphometry revealed that the use of the scaffoldretaining umbrellas led to increased, but not statistically significant, vertical bone regeneration as compared to the use of wide-neck healing caps (1.0 ± 0.4 mm vs 0.6 ± 0.3 mm). The combination of DBM and ng/rhBMP-2 released from the surface of the SLA implant resulted in the greatest amount of vertical bone regeneration (2.1 ± 0.2 mm). The bone-to-implant contact was similar for all groups. Mucosal dehiscence areas with healing cap or custom scaffold retainer exposures were reduced in the presence of ng/rhBMP-2. Conclusions: The combined use of custom perforated Ti scaffold retainers, DBM, and ng/rhBMP-2 regenerated a substantial amount of vertical supracrestal alveolar bone around Ti implants in an intraoral minipig model. Int J Oral Maxillofac Implants 2013;28:432–443. doi: 10.11607/jomi.2782


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help