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Volume 28 , Issue 1
January/February 2013

Pages 5156


Maxillary Sinus Grafting with Biphasic Calcium Phosphate Ceramics: Clinical and Histologic Evaluation in Man

Carlo Mangano, MD, DDS/Vittoria Perrotti, DDS, PhD/Jamil A. Shibli, DDS/Francesco Mangano, DDS/Laura Ricci, DDS/Adriano Piattelli, MD, DDS/Giovanna Iezzi, DDS, PhD


PMID: 23377047
DOI: 10.11607/jomi.2667

Purpose: To evaluate the clinical and histologic aspects of bone formation in maxillary sinus augmentation using macroporous biphasic calcium phosphate (MBCP) comprising hydroxyapatite/tricalcium phosphate (HA/TCP) 60/40 as bone-grafting material. Materials and Methods: A total of 10 patients and 12 sinuses grafted with MBCP in two-stage sinus augmentation were included in the present study. After a healing period of 6 months, bone core biopsies were harvested during implant insertion and evaluated under light microscopy. Results: The histologic examination showed that the MBCP particles were in close contact with new bone in all biopsies. Histomorphometric evaluation demonstrated that newly formed bone constituted 28.3% 2.7%, residual grafted material 27.3% 1.2%, and marrow spaces 45.9% 1.9%. Conclusions: Histologic investigation showed that the MBCP grafted particles were embedded and integrated in the newly formed bone; this bone was in close and tight contact with the biomaterial particles. Data from the preliminary results demonstrated that MBCP is a biocompatible and osteoconductive material that can be successfully used as a grafting material for sinus floor augmentation. Int J Oral Maxillofac Implants 2013;28:5156. doi: 10.11607/jomi.2667

Key words: bone regeneration, biphasic calcium phosphate, human histology, sinus augmentation


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