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Volume 27 , Issue 6
November/December 2012

Pages 1332–1339

Effect of Strontium-Substituted Nanohydroxyapatite Coating of Porous Implant Surfaces on Implant Osseointegration in a Rabbit Model

Guo-li Yang, PhD, DDS/Li-na Song, BA, DDS/Qiao-hong Jiang, PhD, DDS/Xiao-xiang Wang, DE/Shi-fang Zhao, PhD, DDS/Fu-ming He, MD, DDS

PMID: 23189282

Purpose: This study investigated the effects of a strontium-substituted nanohydroxyapatite (Sr-HA) coating, deposited onto porous implant surfaces using an electrochemical process, on implant osseointegration in a rabbit model. Materials and Methods: The surfaces were analyzed by field-emission scanning electron microscopy, x-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), a portable surface roughness tester, and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Thirty implants (half HA-coated and half Sr-HA–coated) were inserted into femurs of 15 rabbits. After 2, 4, and 8 weeks, the femurs were retrieved and prepared for histomorphometric evaluation. Results: Microscopic examination showed a surface topography of rodlike crystals on both surfaces. XRD and FT-IR showed that the phase of the deposits was HA. No differences were found in surface roughness between the two groups. ICP-AES showed that the Sr/(Ca+Sr) molar ratio of Sr-HA coating was 10.1 mol%. Histologic observation showed that new bone appeared on both surfaces after 2 weeks and became mature after 8 weeks. Histomorphometric analysis showed no differences between the two groups in bone-to-implant contact at 2 weeks or in bone area within all threads at 2 and 4 weeks. The Sr-HA coated group had significantly higher bone-to-implant contact at 4 and 8 weeks. Significant differences were also found in bone area at 8 weeks. Conclusion: The present study showed that this Sr-HA coating, deposited using an electrochemical process, has the potential to enhance implant osseointegration. Int J Oral Maxillofac Implants 2012;27:1332–1339

Key words: dental implant, electrochemical process, hydroxyapatite coating, osseointegration, strontium

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