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Volume 18 , Issue 6
November/December 2003

Pages 807–811

Effects of Local Administration of Growth Hormone in Peri-implant Bone: An Experimental Study with Implants in Rabbit Tibiae

Isabel F. Tresguerres, MD, PhD, DDS/Luis Blanco, MD, PhD, DDS/Celia Clemente, MD, PhD/Jesús A. F. Tresguerres, MD, PhD

PMID: 14696655

Purpose: The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH). Materials and Methods: Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy. Results: The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P  .05). Discussion: Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum. Conclusions: Local administration of GH at the time of implant placement could enhance peri-implant bone reaction. INT J ORAL MAXILLOFAC IMPLANTS 2003;18:807–811

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