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Volume 27 , Issue 2
March/April 2012

Pages 401-410

Porous Titanium Granules in the Surgical Treatment of Peri-Implant Osseous Defects: A Randomized Clinical Trial

Johan Caspar Wohlfahrt, DDS, MS/Ståle Petter Lyngstadaas, DDS, PhD, BEng/Hans Jacob Rønold, DDS, PhD/Erik Saxegaard, DDS, PhD/Jan Eirik Ellingsen, DDS, PhD/Stig Karlsson, DDS, PhD/Anne Merete Aass, DDS, PhD

PMID: 22442781

Purpose: Porous titanium granules (PTG) may have potential as an osteoconductive bone graft substitute to treat peri-implant osseous defects. The aim of this study was to analyze clinical and radiographic outcomes of peri-implant osseous defects after treatment with PTG. Materials and Methods: This prospective, randomized, case-control, clinical 12-month study compared open-flap debridement and surface decontamination with titanium curettes and 24% ethylenediaminetetraacetic acid gel (n = 16) to the same protocol but with the addition of PTG (n = 16). One-, two-, and three-wall infrabony defects were included. Patients were given amoxicillin and metronidazole 3 days before surgery and for 7 days afterwards. Implants were submerged and allowed to heal for 6 months. Probing pocket depths, bleeding on probing, implant stability using resonance frequency analysis, and radiographic evaluation were performed at baseline and at 12 months. The threshold for significance was set at .05. Results: Change in radiographic defect height and percent fill of the peri-implant osseous defect significantly favored patients treated with PTG. Both treatment modalities demonstrated significant improvements in probing pocket depth, but significant differences between groups were not observed. The PTG-treated implants showed an increase in implant stability quotient (ISQ) of 1.6 units, compared with a decrease of 0.7 ISQ for the control group. No adverse effects were associated with PTG treatment. Conclusions: Reconstruction with PTG resulted in significantly better radiographic peri-implant defect fill compared with controls; however, the results do not necessarily imply reosseointegration or osseointegration of PTG particles. Improvements in clinical parameters were seen in both groups, but no differences between groups were demonstrated. Int J Oral Maxillofac Implants 2012;27:401–410

Key words: osseous defects, peri-implantitis, porous titanium granules

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