LOGIN
 
Share Page:
Back

Volume 18 , Issue 4
July/August 2003

Pages 500504


Bone Morphogenetic Protein-4 Gene Polymorphism and Early Marginal Bone Loss Around Endosseous Implants

Hitomi Shimpuku, DDS, PhD/Yasuhiro Nosaka, DDS, PhD/Tatsuya Kawamura, DDS, PhD/Yoichi Tachi, PhD/Mitsuko Shinohara, PhD/Kiyoshi Ohura, DDS, PhD


PMID: 12939000

Purpose: At stage II surgery during dental implant treatment, early marginal bone loss around the implant occasionally occurs despite a lack of apparent causal events, and the etiology of this bone loss is unclear. This study was designed to investigate whether the bone morphogenetic protein-4 (BMP-4) genetic polymorphism is associated with early marginal bone loss around implants. Materials and Methods: The BMP-4 polymorphism was detected by restriction fragment length analysis using HphI digestion after polymerase chain reaction. A total of 262 implants were placed in 41 patients, and early marginal bone loss was observed in 25 of the 109 maxillary implants and 14 of the 153 mandibular implants. Results: In the mandible, the patients with the BMP-4 AV genotype had a significantly higher rate of occurrence of marginal bone loss than those with the BMP-4 VV genotype (P = .012). According to multiple logistic regression analyses, the odds ratio of the AV versus the VV BMP-4 genotype was 8.106 between patients with and those without bone loss in the mandible (95% CI = 1.30 to 50.51; P = .025). Discussion: These results suggest that the BMP-4 genetic polymorphism influences early marginal bone loss around implants. Conclusion: While perhaps premature in recommendation, genetic screening before implant surgery may prove to be a very useful aid to consider the risk of implant treatment. (INT J ORAL MAXILLOFAC IMPLANTS 2003;18:500504)


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help