Home Subscription Services
 
   

 
Oral Health and Preventive Dentistry
OHPD Home Page
About the Editor
Editorial Board
Submit
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
 
 
 
 
 
FacebookTwitter

Publication:
Oral Health & Preventive Dentistry

Year 2004
Volume 2 , Issue 4

Back
Pages: 369 - 376

An Experimental Gingivitis Study to Evaluate the Clinical Effects of a Stannous Fluoride Dentifrice

Niklaus P. Lang / Elena Anton / Yvonne Gabriel / Bjarni E. Pjetursson / J. Leslie Winston / Tao He

Purpose:
A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis.

Material and Methods:
Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate® Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer).

Results:
After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate® Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate® Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PlI scores increased almost linearly in all three groups without yielding any statistically significant differences.

Conclusions:
The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate® Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/copolymer (Colgate® Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.

Key words:
prevention, gingivitis, stannous fluoride, dentifrice, plaque, discolorations

 

  © 2014 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog