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Quintessence Publishing: Journals: OHPD


Oral Health & Preventive Dentistry

Edited by Anton Sculean, Poul Erik Petersen, Avijit Banerjee

ISSN (print) 1602-1622 • ISSN (online) 1757-9996


Spring 2004
Volume 2 , Issue 1

Pages: 49-58
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A Systematic Review of the Effectiveness of Anticalculus Dentifrices

Netuveli, Gopalakrishnan S. / Sheiham, Aubrey

To assess the evidence on the effectiveness of commercially available anticalculus dentifrices. Systematic search for published and unpublished epidemiological data in 7 electronic databases, 5 journals, and the bibliographies of retrieved papers and by making contact with subject experts in this field. Thirty-two reports were identified containing comparisons of one or more active agents with a placebo dentifrice and calculus measured using the Volpe-Manhold Index (VMI). Random effect model for 3-month studies showed an effect size of 0.6 for all comparisons. The effect sizes varied from 0.3 for dentifrices with zinc chloride 0.5% to 1.1 for pyrophosphate 1.3% and copolymer 1.5% dentifrices. Meta-analysis of all the studies with 6-month follow-up gave an effect size of 1.1 (1.5 to 0.8) and for 12-month follow-up the effect size was 13.6 (21.4 to 5.8). Anticalculus dentifrices containing pyrophosphates, zinc compounds and/or co-polymers were effective in significantly reducing calculus scores (VMI).

Keywords: calculus, anti-calculus, dentifrices, pyrophosphate, zinc citrate, co-polymer, toothpaste, systematic review

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