Home Subscription Services
 
   

 
Oral Health and Preventive Dentistry
OHPD Home Page
OHPD Pre-Print
About the Editor
Editorial Board
Submit
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
Official Website
 
 
 
 
 
FacebookTwitter
Quintessence Publishing: Journals: OHPD

 

Oral Health & Preventive Dentistry

Edited by Anton Sculean, Poul Erik Petersen, Avijit Banerjee

ISSN (print) 1602-1622 • ISSN (online) 1757-9996

Publication:

September/October 2015
Volume 13 , Issue 5



Pages: 385–393
PMID: 25884045
DOI: 10.3290/j.ohpd.a34055
Back
Share Abstract:

New Non-Bisphosphonate Drugs That Produce Osteonecrosis of the Jaws

Lucía Ramírez / Rosa María López-Pintor / Elisabeth Casañas / Lorenzo de Arriba / Gonzalo Hernández

Purpose: The aim of this paper was to review the current literature associating the non-bisphosphonate cancer-treatment drugs Denosumab, Bevacizumab and Sunitinib (used with or without bisphosphonate [BP]) with the presence of osteonecrosis of the jaws (ONJ) in patients.

Materials and Methods: A literature review was conducted using the keywords osteonecrosis of the jaws, oral biphosphosnates, Denosumab, Bevacizumab and Sunitinib. Articles were obtained that reported cases of ONJ associated with the use of Denosumab, Bevacizumab and Sunitinib.

Results: The literature shows that Denosumab can cause ONJ associated with triggers such as microtraumas or dental extractions. The combination of the drug along with zoledronic acid may have a synergistic effect. Bevacizumab may cause ONJ; however, there is much controversy regarding its synergistic action when used with BP. Sunitinib causes ONJ, and together with BP could increase the risk of developing lesions.

Conclusion: Denosumab, Sunitinib or Bevacizumab are causal agents in the development of ONJ. The combination of any of these along with BPs could increase the risk of developing ONJ over that posed by BP treatment alone.

Full Text PDF File | Order Article

 

 
  © 2019 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog