Home Subscription Services

Oral Health and Preventive Dentistry
OHPD Home Page
OHPD Pre-Print
About the Editor
Editorial Board
Author Guidelines
Submission Form
Reprints / Articles
Official Website
Quintessence Publishing: Journals: OHPD


Oral Health & Preventive Dentistry

Edited by Anton Sculean, Poul Erik Petersen, Avijit Banerjee

ISSN (print) 1602-1622 • ISSN (online) 1757-9996


Winter 2004
Volume 2 , Issue 4

Pages: 369-376
DOI: 10.3290/j.ohpd.a9764
Share Abstract:

An Experimental Gingivitis Study to Evaluate the Clinical Effects of a Stannous Fluoride Dentifrice

Lang, Niklaus P./Anton, Elena/Gabriel, Yvonne/Pjetursson, Bjarni E./Winston, Leslie J./He, Tao

A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis.

Material and Methods:
Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) ColgateŽ Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer).

After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the ColgateŽ Total group by 39.7%. Gingival bleeding was also reduced relative to the ColgateŽ Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PlI scores increased almost linearly in all three groups without yielding any statistically significant differences.

The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (ColgateŽ Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/copolymer (ColgateŽ Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.

Key words:
prevention, gingivitis, stannous fluoride, dentifrice, plaque, discolorations

Full Text PDF File | Order Article


  © 2017 Quintessence Publishing Co Inc

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog