LOGIN
 
Share Page:
Back

Volume 25 , Issue 2
Spring 2011

Pages 131–140


Unexplained Somatic Comorbidities in Patients with Burning Mouth Syndrome: A Controlled Clinical Study

Michele D. Mignogna, MD, DMD/Annamaria Pollio, DMD/Giulio Fortuna, DMD/Stefania Leuci, DMD, PhD/Elvira Ruoppo, DMD, PhD/Daniela Adamo, DMD/Claudia Zarrelli, MD, DMD, PhD


PMID: 21528120

Aims: To evaluate the prevalence of unexplained extraoral symptoms in a group of patients with burning mouth syndrome (BMS) and compare the prevalence with that in patients with oral lichen planus (OLP) and age- and gender-matched controls. Methods: The occurrence of extraoral symptoms was analyzed in a group of 124 BMS patients, a group of 112 oral lichen planus (OLP) patients, and a group of 102 healthy patients. Oral symptoms were collected by a specialist in oral medicine and a general dentist, while data concerning unexplained extraoral symptoms were gathered by each specialist ward, ie, ophthalmology, gynecology, otolaryngology, gastroenterology, neurology, cardiology, internal medicine, and dermatology. A Fisher exact test (α = .05) and Kruskal–Wallis test (α = .05) were performed for statistical analysis. Results: In the BMS group, 98 (96.1%) patients reported unexplained extraoral symptoms, while 4 (3.9%) patients reported only oral symptoms. A painful symptomatology in different bodily regions was reported more frequently by BMS patients (83.3%) than by OLP patients (1.8%) and healthy patients (11.7%) (P < .0001). The differences in the overall unexplained extraoral symptoms between BMS (96.1%) and OLP patients (9.3%) (P < .0001) and between BMS (96.1%) and healthy patients (15.7%) (P < .0001) were statistically significant. The unexplained extraoral symptoms in BMS patients consisted of pain perceived in different bodily areas (odds ratio [OR]: 255; 95% confidence interval [CI]: 58.4–1112), ear-nose-throat symptoms (OR: 399.7; 95%CI: 89.2–1790), neurological symptoms (OR: 393; 95% CI: 23.8–6481), ophthalmological symptoms (OR: 232.3; 95% CI: 14.1–3823), gastrointestinal complaints (OR: 111.2; 95% CI: 42.2–293), skin/gland complaints (OR: 63.5; 95% CI: 3.8–1055), urogenital complaints (OR: 35; 95% CI: 12–101), and cardiopulmonary symptoms (OR: 19; 95% CI: 4.5–82). Conclusion: The great majority of BMS patients presented with several additional unexplained extraoral comorbidities, indicating that various medical disciplines should be involved in the BMS diagnostic process. Furthermore, the results suggest that BMS may be classified as a complex somatoform disorder rather than a neuropathic pain entity. J OROFAC PAIN 2011;25:131–140

Key words: BMS, burning mouth syndrome, extraoral symptoms, somatic comorbidities


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2017 Quintessence Publishing Co, Inc

JOFPH Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help