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Volume 8 , Issue 4
Fall 1994

Pages 391-396


Traumatic dysesthesia of the trigeminal nerve

Canavan/Graff-Radford/Gratt


PMID: 7670427

Traumatic injury to the peripheral nerves often results in persistent discomfort. Substance P has been implicated as a mediator of pain, and depletion of this neurotransmitter has been shown to reduce pain. Subjects suffering from traumatic dysesthesia of the trigeminal nerve were treated with capsaicin, a substance P depleter with significant long-term effects. This form of therapy may be used individually or in combination with other pharmacologic interventions in the treatment of traumatic trigeminal dysesthesia.


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