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Volume 13 , Issue 2
Spring 1999

Pages 83-88

Trazodone in burning mouth pain: a placebo-controlled, double-blind study.

Tammiala-Salonen T, Forssell H.

PMID: 10425979

AIMS: An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain. METHODS: Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks. RESULTS: There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness. CONCLUSION: In this controlled trial, trazodone failed to relieve burning mouth pain.

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