Home Subscription Services
 
   

 
Journal of Oral & Facial Pain and Headache
OFPH Home Page
About the Editor
Editorial Board
Accepted Manuscripts
Submit
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
 
 
 
 
 
FacebookTwitterYouTube
Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Publication:
Fall 2008
Volume 22 , Issue 4

Back
Share Abstract:

Nerve Growth Factor–Evoked Masseter Muscle Sensitization and Perturbation of Jaw Motor Function in Healthy Women

Peter Svensson, DDS, PhD, Dr Odont/Eduardo Castrillon, DDS, MS, PhD/Brian E. Cairns PhD, RPh

PMID: 19090407

Aim: To replicate and extend previous findings of nerve growth factor (NGF)-induced mechanical sensitization in healthy young men to women and test for associations between mechanical sensitization and oral motor function. Combined these data would indicate if injection of NGF into the masseter muscle is a valid model of muscle pain related to temporomandibular disorders (TMD). Methods: A double-blind, placebo-controlled study was conducted on 14 healthy women. Each subject received an injection of NGF (5 µg in 0.2 mL) into 1 masseter muscle and buffered isotonic saline (control, 0.2 mL) into the other. Pressure pain thresholds (PPT) and pressure pain tolerance (PPTOL) as well as self-assessed pain intensity (numeric rating scale of 1 to 10) with the jaw at rest and in relation to various motor activities (chewing, yawning, talking, swallowing, drinking, and smiling) were recorded prior to and 3 hours, 1 day, 7 days, 14 days, and 21 days postinjection. ANOVAs were used to test data. Results: It was found that NGF significantly reduced PPT and PPTOL 3 hours, 1 and 7 days postinjection (P < .001). Numerical rating scale (NRS) scores during chewing and yawning were significantly increased 3 hours and 1 day following NGF injection (P < .001). After 3 hours, there were significant correlations between relative changes in PPTs and NRS scores during chewing (r = –0.556; P = .037), between relative changes in PPTOL and NRS scores during yawning (r = –0.607; P = .020), and between relative changes in PPTOL and maximum unassisted jaw-opening capacity (r = 0.868; P < .001). Conclusion: This study shows that injection of NGF into the masseter muscle of women causes local signs of mechanical allodynia and hyperalgesia that persist for at least 7 days as well as pain during strenuous jaw movement. Taking the authors’ previous results on NGF effects in men into consideration, these findings lend additional support to the suggestion that this model may serve as a proxy of some of the clinical features of TMD-related muscle pain. J Orofac Pain 2008;22: 340–348

Key words: allodynia, jaw motor function, nerve growth factor, pain measurement, TMD pain

Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.
  © 2014 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog