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Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Publication:
Fall 2006
Volume 20 , Issue 4

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Influence of Intramuscular Nerve Growth Factor Injection on the Response Properties of Rat Masseter Muscle Afferent Fibers

Mandeep K. Mann, MSc / Xu-Dong Dong, BDS, PhD / Peter Svensson, DDS, PhD, Dr Odont / Brian E. Cairns, PhD, RPh

Pages: 325336
PMID: 17190031

Aims: To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization. Methods: Electrophysiologic recordings were made from masseter afferents and a randomized, blinded approach was used to test the effects of intramuscular injection of NGF (2.5 or 25 g/mL) into the rat masseter muscle on the MT of masseter afferents (n = 65) and plasma protein extravasation. Results: The plasma protein extravasation data and electrophysiological recordings indicated that rat NGF injection was not inflammatory and did not evoke afferent discharge or induce mechanical sensitization (as reflected in a decreased MT) in masseter afferents in either male or female rats. To investigate whether the lack of effect of NGF injection might be due to differences between human and rat NGF, additional experiments with human NGF injection (25 g/mL) were undertaken. Intramuscular injection of human NGF into the rat masseter muscle also failed to evoke afferent discharges; however, it did decrease the MT of masseter afferent fibers. Conclusion: The finding that neither rat nor human NGF excited putative nociceptive masseter afferent fibers is consistent with a previous report that intramuscular NGF injections are not acutely painful in human subjects. The ability of human NGF injection into the rat masseter muscle to induce afferent mechanical sensitization suggests that this experimental approach may be useful for the study of peripheral mechanisms of myofascial pain and tenderness associated with temporomandibular disorders. J Orofac Pain 2006;20:325336

Key words: afferent fibers, masseter muscle, muscle pain, nerve growth fibers, temporomandibular disorders

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