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Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Summer 2006
Volume 20 , Issue 3

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Effects of Local Serotonin Administration on Pain and Microcirculation in the Human Masseter Muscle

Malin Ernberg, DDS, PhD / Britt Hedenberg-Magnusson, DDS, PhD / Hiroshi Kurita, DDS, PhD / Sigvard Kopp, DDS, PhD

Pages: 241–248
PMID: 16913434

Aims: To investigate whether exogenously administered 5-hydroxy-tryptamine (5-HT) at high or low concentration influences pain and microcirculation in the human masseter muscle. Methods: In 12 healthy female subjects, 5-HT in 2 concentrations (0.1 µmol/L and 1,000 µmol/L) and isotonic saline were injected into the masseter muscles in a randomized and balanced double-blind manner. The pain intensity after injections was recorded with Borg’s rating scale, and intramuscular blood flow was monitored continuously during the experiment with a laser-Doppler technique. Nonparametric statistics were used for analyses. Results: Administration of 5-HT at 1,000 µmol/L induced significantly more pain than saline (Wilcoxon: P < .05), while there was no difference between 5-HT at 0.1 µmol/L and saline. The blood flow did not change significantly after injection of 5-HT at either concentration compared to saline. However, changes in pain intensity and blood flow were positively correlated after injection of 5-HT at 1,000 µmol/L (Spearman: P < .05). Conclusion: Intramuscular administration of 5-HT at 1,000 µmol/L into the human masseter muscle induced pain, but 5-HT did not have any effect on local blood flow at either concentration. J Orofac Pain 2006;20:241–248

Key words: ischemia, laser-Doppler flowmetry, masseter muscle, pain, serotonin

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