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Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Publication:
Spring 2006
Volume 20 , Issue 2

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The Effects of Age and Sex on the Expression of Aromatase in the Rat Temporomandibular Joint

Shi-Bin Yu, MDS / Mei-Qing Wang, DDS, PhD, Dr Odont / Wei Zhao, MDS / Hong-Tao Cao, DDS, PhD / Yan-Li Liu, MDS

Pages: 156165
PMID: 16708833

Aims: To investigate the expression of aromatase in temporomandibular joints(TMJs) of male and female rats of different ages. Methods: The expression of aromatase in terms of protein and mRNA was examined by immunohistochemistry, Western blot, and in situ hybridization in the TMJs of Sprague-Dawley rats. The expression level of aromatase protein was also quantified by the density of aromatase-positive chondrocytes in TMJ condylar cartilage. A tritiated water assay was used to analyze the activity of aromatase in cartilage chondrocytes. Results: Strong aromatase protein and mRNA hybridization signals were detected in hypertrophic and mature chondrocytes in all the cases examined. The density of aromatase-positive chondrocytes was relatively stable at higher levels before 8 weeks of age. The density decreased gradually in females after 8 weeks of age but not in males. Conclusion: These results demonstrate that aromatase is expressed intensely in condylar cartilage and suggest that it may play an important role in pathophysiological mechanisms in condylar cartilage. J Orofac Pain 2006;20:156165

Key words: aromatase, cartilage, chondrocytes, estrogen, temporomandibular joint

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