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Volume 36 , Issue 1
Winter 2022

Pages 6777

Association Between Anxiety and Descending Pain Modulation of Thermal Stimuli in Patients with Burning Mouth Syndrome: A Cross-Sectional Study

Kana Ozasa, DDS/Noboru Noma, DDS, PhD/Momoyo Kobayashi, DDS/Keita Takizawa, DDS/Andrew Young, DDS, MSD/Eli Eliav, DMD, PhD/Yoshiki Imamura, DDS, PhD

DOI: 10.11607/ofph.3050

Aims: To investigate the predictive power of depression and anxiety for conditioned pain modulation (CPM) and to examine the relationships of CPM at 40C and CPM at 47C with age, disease-related pain, pain duration, and psychosocial factors in burning mouth syndrome (BMS). Methods: A total of 22 patients with BMS and 22 healthy female controls participated in this study. Temporal summation was used as the test stimulus for CPM, and subsequent exposure either to a nonpainful (40C) or a painful (47C) Peltier thermode was used as the conditioning stimulus. CPM was calculated as the difference in pain perception following the conditioning stimulus. Psychosocial factors were examined using the Profile of Mood States (POMS) and the State-Trait Anxiety Inventory (STAI). Results: State anxiety and tension-anxiety scores were significantly higher for patients with BMS than for control participants. Multiple regression analyses showed that CPM47C was affected by vigor, fatigue, confusion, and trait anxiety (adjusted R2 = 0.685, F = 5.147, P = .098). The corresponding analysis for CPM40C showed that the model was not predictive for the following variables: disease-related pain, pain duration, or components of the POMS or STAI. A significant positive correlation was found between CPM47C and trait anxiety, suggesting that trait anxiety negatively affected the endogenous pain modulation system. Conclusion: Increases in trait anxiety reduced the CPM effect. These findings suggest that CPM impairments and increases in trait anxiety are involved in the development of BMS.

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