Aims: To study the effect of dexamethazone and dipyrone on sensory
changes in the innervation territories of the inferior alveolar,
infraorbital, and lingual nerves caused by third molar extractions.
Methods: Fourteen patients (8 men and 6 women) were divided
randomly into 2 groups. The first group received dipyrone preoperatively,
while the second group received dipyrone and dexamethazone
preoperatively. All patients in the study received a prophylactic
preoperative dose of amoxicillin (500 mg) as well as
dipyrone postoperatively. In all patients, a single mandibular third
molar was removed, while in 2 patients the contralateral third
molar was removed at a subsequent time. Electrical detection
thresholds were assessed in the inferior alveolar, lingual, and
infraorbital nerve regions prior to surgery and 2 and 8 days following
surgery. The level of perioperative pain, difficulty of
extraction, and distance of molar root apices from the inferior
alveolar nerve canal were also assessed. Results: Patients who
received only dipyrone had significantly reduced lingual and inferior
alveolar nerve electrical detection thresholds 2 days after
surgery, which returned to nearly baseline values by the eighth day
postoperatively. In patients who received dexamethasone, no significant
reduction in the electrical detection threshold was found.
Conclusion: Preoperative treatment with dexamethasone and
dipyrone but not dipyrone alone prevents sensory hypersensitivity
following third molar extraction. J OROFAC PAIN 2004;18:62–68.