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Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Publication:
Fall 2012
Volume 26 , Issue 4

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Effect of Estrogen and Dietary Loading on Condylar Cartilage

Marko Orajärvi, DDS/Shi-Bin Yu, MDS, PhD/Xiaodong Liu, PhD/Petri Tiilikainen, DDS/Meiqing Wang, DDS, MD, PhD/Aune Raustia, DDS, PhD/Pertti Pirttiniemi, DDS, PhD

Pages: 328-336
PMID: 23110273

Aims: To study the effect of estrogen deficiency and altered temporomandibular joint loading on the histomorphology of condylar cartilage and on the expression of types II and X collagen and matrix metalloproteinase-3 (MMP-3). Methods: Thirty-six female rats were divided into four groups: ovariectomized rats on a normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy was performed at the age of 60 days. Repeated measures ANOVA was used to analyze the data. Results: The condylar cartilage in the ovariectomized normal diet group showed a significantly higher number of cells than in the nonovariectomized control rats (P < .001). The proportional amount of MMP-3 expression was significantly higher in the ovariectomized rats than in the nonovariectomized control rats in both diet groups (P < .001). The area covered by types II and X collagen was significantly higher in the experimental groups than in the control groups (P < .01). Conclusion: Condylar cartilage is sensitive to both estrogen level and dietary loading. J Orofac Pain 2012;26:328–336

Key words: estrogen, joint loading, mandibular condylar cartilage, MMP-3, type II collagen, type X collagen

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