Share Page:

Volume 17 , Issue 3
Summer 2003

Pages 251253

The Effect of Exogenous Glucosamine Hydrochloride on the Proteoglycan Concentration of the Articular Disc of the Rabbit Temporomandibular Joint

Meltem Deniz, DMD, MS/Theodore R. Oegema, Jr, PhD/Eric L. Schiffman, DDS, MS/John O. Look, DDS, PhD

PMID: 14520771

Aims: To test the effect of glucosamine hydrochloride (glucosamine- HCl) on the proteoglycan (PG) concentration of the articular disc of non-arthritic temporomandibular joints (TMJs) in rabbits. Methods: Twenty-four of 48 New Zealand white 10- to 12-week-old male rabbits (2.2 kg average) were injected with the irritant chymopapain in the knee joint. Both groups of 24 rabbits were divided into 3 groups of 8 animals. The rabbits were fed a control diet or a diet supplemented with glucosamine-HCl incorporated at a level to provide 20 mg/kg (approximating the recommended dose 500 mg/tid/70 kg man) or 100 mg/kg, for 8 weeks. Sulfated glycosaminoglycans (GAGs) were assayed in protease K digests of the TMJ articular disc by dimethylmethylene blue method to quantify PG concentration. The groups were compared with 2-way analysis of variance. Results: Glucosamine-HCl did not cause a significant change in the PG concentration of the TMJ articular disc (P  .8). There was also no detectable effect of chymopapain injection to the knee joint on the TMJ (P  .07) and no interaction between glucosamine-HCl treatment and chymopapain injection (P  .3). Conclusion: Glucosamine-HCl has no effect on PG concentration of the articular disc of non-arthritic TMJ in rabbits. J OROFAC PAIN 2003;17:251253.

Full Text PDF File | Order Article


Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.


© 2017 Quintessence Publishing Co, Inc

Current Issue
Ahead of Print
Author Guidelines
Accepted Manuscripts
Submission Form
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us