Home Subscription Services

Journal of Oral & Facial Pain and Headache
OFPH Home Page
About the Editor
Editorial Board
Accepted Manuscripts
Author Guidelines
Submission Form
Reprints / Articles
Quintessence Publishing: Journals: OFPH
Journal of Oral & Facial Pain and Headache

Edited by Barry J. Sessle, BDS, MDS, BSc, PhD, FRSC

Official Journal of the American Academy of Orofacial Pain,
the European, Asian, and Ibero-Latin Academies of Craniomandibular
Disorders, and the Australian Academy of Orofacial Pain

ISSN 2333-0384 (print) • ISSN 2333-0376 (online)

Summer 2003
Volume 17 , Issue 3

Share Abstract:

Capsaicin Receptor VR1 and ATP Purinoceptor P2X3 in Painful and Nonpainful Human Tooth Pulp

Tara Renton, MDS, PhD, FDS RCS, FRACDS (OMS)/Yiangos Yiangou, PhD/Preston A. Baecker, PhD/Anthony P. Ford, PhD/Prareen Anand, MA, MD, FRCP

Pages: 245250
PMID: 14520770

Aims: To investigate the levels of the capsaicin or vanilloid receptor- 1 (VR1) and the ATP-gated purinoceptor P2X3 in painful and nonpainful human tooth pulps. Methods: Immunohistochemistry with specific antibodies and image analysis was used to quantify VR1- and P2X3-positive nerve fibers in painful (n = 13) and nonpainful (n = 33) human tooth pulps, and VR1 immunoreactivity was compared with immunoreactivity for the structural neuronal marker peripherin. Results: Strong VR1-like immunoreactivity was documented for the first time in dental pulp neurons. Weaker P2X3-like immunoreactivity was also detected in fewer nerve fibers. The ratio of VR1 to peripherin immunoreactivity was not significantly different between nonpainful and painful tissues (mean SE % area of VR1 to peripherin; nonpainful 53.4 4.7%, n = 33; pulpitis 35.1 7.1%, n = 13; P = .07). Conclusion: The presence of VR1 and P2X3 in fibers of human tooth pulp suggest that they may play a role in perception of dental pain, but further studies, including quantitation of their ligands, are necessary to elucidate any role they may play in pathophysiologic states. J OROFAC PAIN 2003;17:245250.

Full Text PDF File | Order Article


Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.
  © 2017 Quintessence Publishing Co Inc

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog