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Oral & Craniofacial Tissue Engineering

Edited by Ole T. Jensen, DDS, MS

Official Journal of the Tissue Engineering Society, the Chinese Society of Oral Biomedicine, and the Japanese Society of Regenerative Medicine

ISSN (print) 2158-3722 • ISSN (online) 2158-3706

Oral & Craniofacial Tissue Engineering
Summer 2011
Volume 1 , Issue 2

Share Abstract:

Bone Marrow Aspirate Concentrate Used with Bovine Bone Mineral to Reconstruct Vertical and Horizontal Mandibular Defects: Report of Two Techniques

Sebastian Sauerbier, MD, DDS/Bernd Giessenhagen, DDS/Wolfgang Gutwerk, DDS/Petra Rauch, DMD, MSc/Samuel P. Xavier, DDS/Toshiyuky Oshima, DDS/Heiner Nagursky/Ralf Gutwald, MD, DDS/Rainer Schmelzeisen, MD, DDS

Pages: 118122

Purpose: Following initial positive reports of the use of bone marrow aspirate concentrate (BMAC) in combination with bovine bone mineral (BBM) in augmentation procedures, the technique was evaluated in patients with mandibular deficiency. Materials and Methods: Two adult patients required surgical correction of a deficient alveolar ridge (one patient showed horizontal deficiency only, and the other patient presented with horizontal and vertical deficiency) prior to dental implant placement. In both patients, the reconstruction was performed with BBM in combination with mononuclear cells concentrated by the BMAC method using different techniques. Results: The patients recovered well from all surgical procedures. Histologically, there was uniform bone formation, which allowed placement of dental implants. Conclusion: The results suggest that the use of BMAC in combination with BBM, without autogenous bone, has the potential to restore horizontal and vertical mandibular alveolar defects, providing a functional bone structure and allowing dental implant placement for subsequent prosthetic rehabilitation. Oral Craniofac Tissue Eng 2011;1:118122

Key words: bone marrow, bovine bone matrix, cell transplantation, horizontal augmentation, mandible, mesenchymal stem cells

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