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Quintessence Publishing: Journals: OBM


Oral Biosciences & Medicine

Edited by Birgitte Nauntofte, Jesper Reibel. Peter A. Reichart, Jim Sciubba, and Joanna M. Zakrzewska

Official publication of the European Society for Oral Laser Applications

ISSN 1742-3287

Oral Biosciences & Medicine

Year 2004
Volume 1 , Issue 4

Pages: 249 - 257

The Significance of Gingival Crevicular Fluid and IL-1â, TNF-á and PGE2 in Periodontal Disease. A Literature Review

Mahmoud N. Younis / Eli E. Machtei / Orit Oetlinger-Barak / Micha Peled


To review the literature regarding cytokines and PGE2 levels in gingival crevicular fluid (GCF) in healthy and diseased periodontium.

A Medline search ending at March 2004 was performed, in the English literature, regarding IL-1, TNF- and PGE2 in the GCF, and the data was reviewed systematically.

Low levels of these markers were reported in healthy periodontium. Significant increase in the amount of IL-1 and PGE2 was noted in gingivitis and periodontitis. Most of the studies have shown that there is a marked decrease in IL-1 and PGE2 levels of periodontal disease patients after therapy, while inconsistent results were found for TNF-.

The IL-1, TNF- and PGE2 levels may be indicative of periodontal status, and amount rather than concentration being more reliable in reflecting the real status of the periodontium.

Key words:
, TNF-


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