Aims: Recently, the use of selective serotonin reuptake inhibitors (SSRIs) has been associated with the occurrence or worsening of bruxism. The aim of this study was to obtain a first indication of the prevalence of SSRI-associated bruxism reported to family physicians, the main prescribers of SSRIs. Methods: A questionnaire, with questions about prescription rate, already registered adverse reactions, and bruxism-related side effects of 4 different types of SSRIs, was sent to all family physicians in greater Amsterdam (n = 391). Results: With a response rate of 42.5%, frequent observations of already registered side effects were found. In addition, 5 family physicians (3.2%) reported the occurrence of bruxism in relation to the use of SSRIs. Conclusion: The use of SSRIs might be associated with the occurrence of bruxism. A case report is provided that corroborates this suggestion.