Purpose: Oral lichen planus is a chronic disease and can be debilitating. Topical corticosteroids are most frequently used for treatment, but are not always effective. The purpose of the present study was to assess the efficacy of laser therapy in the treatment of corticosteroid-resistant oral lichen planus. Materials and Methods: Six patients with corticosteroid-resistant oral lichen planus were treated with CO₂ laser, and standard laser safety protocols were used. The laser was used in a defocused, continuous mode at 4 W in order to vaporize the oral lichen planus lesion. Patients were assessed using VAS scores at baseline and at 2, 4, 12, and 24 weeks after treatment. All patients had an excellent response to therapy. Pain relief and reduced burning sensation were observed after 3 months of therapy in five patients, but in one patient, erosions required additional treatment with a topical steroid before the burning sensation completely resolved. There were no adverse effects. Conclusion: CO₂ laser treatment may be useful in the treatment of corticosteroid therapy-resistant oral lichen planus.