Purpose: Since root resection is one of the most frequent surgical interventions in the oral cavity, this study aimed to determine the analgesic effect of soft laser after such surgical treatment. Materials and Methods: A total of 54 patients underwent root resection of a maxillary anterior tooth. In 27 examinees of the experimental group, the operative area was postoperatively irradiated with soft laser, whereas in the rest of the patients, the treatment procedure was only simulated. Results and Conclusion: The investigation showed a high percentage of postoperative pain reduction in the patients of the laser-treated group, so it can be concluded that soft laser is a completely safe means of treatment, which, combined with standard methods of treatment, may have very favorable effects on the postoperative pain reduction after root resection.