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Quintessence Publishing: Journals: JOLA

 

The Journal of Oral Laser Applications

Edited by Prof Dr Andreas Moritz and Prof G. Lynn Powell

Official publication of the European Society for Oral Laser Applications

ISSN (print) 1473-7809 • ISSN (online) 1867-5611

Publication:
JOLA
Fall 2007
Volume 7 , Issue 3

Pages: 175-181
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Low-level Infrared Laser Therapy for Chemo- or Radiotherapy-induced Oral Mucositis: A Randomized, Placebo-controlled Study

Kuhn, Alessandra / Vacaro, Giovana / Almeida, Denise / Machado, Álvaro / Braghini, Pedro B. / Shilling, Marco A. / Guerra, Lieverson / Brunetto, Algemir Lunardi

Purpose: The study was conducted to determine whether low-intensity laser therapy (LLLT) can reduce the duration of chemotherapy- and/or radiotherapy-induced oral mucositis (OM). Materials and Methods: A placebo-controlled randomized study was carried out using LLLT or control (placebo treatment). Patients older than 18 years of age treated with chemo- and/or radiotherapy between October 2005 and May 2006 were eligible as soon as they developed OM. Patients received intervention for 5 days. The laser group was treated with GaAlAs laser, wavelength: 830 nm (infrared), power: 100 mW, dose: 4 J/cm2. The control group received a placebo treatment. The grade of OM was clinically assessed according to the Common Toxicity Criteria Scale of the National Cancer Institute. Thirty-four patients developed OM and were available for analysis; 22 (65%) patients had a diagnosis of solid tumors and 12 (35%) leukemia or lymphoma. The mean age was 41 (± 20) years. Eighteen patients were randomized in the laser group and 16 patients in the control group. Results: Once OM was diagnosed, the patients had daily OM grading assessments before laser or placebo application, and thereafter until complete healing of lesions. On day 7 after OM diagnosis, 32% of patients presented OM in the laser group and 94% of patients in the placebo group (p = 0.001). In the laser group, the mean of OM duration was 6.8 ± 2.2 days, and in the placebo group 11.5 ± 3.5 days (p < 0.001). Conclusion: Our study has shown evidence that laser therapy in addition to oral care can decrease the duration of chemotherapy- and radiotherapy-induced oral mucositis. These results should encourage clinicians to use this technique to improve the quality of life of cancer patients during oncology treatment.

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