Purpose: The aim of this clinical study is to compare the desensitizing effects on dentin and dental cervices of different desensitizing gels or liquids with the use of Er:YAG laser. Materials and Methods: In this split-mouth-design study, 25 patients suffering from hypersensitive dental cervices or dentin were treated with DentinProtector (Vivadent, Liechtenstein) in the first quadrant, in the second quadrant with Er:YAG laser [(KEY III, KaVo, Biberach) at 80 mJ and 3 Hz, Handpiece 2060 with water irrigation, defocused, 2 min per tooth)], in the third quadrant with Duraphat, and the fourth quadrant served as an untreated control group. Results: Compared to the control group, all three treatment methods showed reduction of discomfort after 6 months. Conclusion: Desensitizing with Er:YAG laser was effective. In comparison to the use of Duraphat and DentinProtector, the good results persisted longer. It seems that the Er:YAG laser is a suitable tool for treatment of dentin hypersensitivity.

Keywords: Er:YAG laser, hypersensitivity, DentinProtector, Duraphat, desentizising effects, maintenance