Purpose: Non-vital endodontically treated posterior teeth with complete loss of coronal hard tissues were prepared with a circular equigingival butt margin and central retention cavity of the entire pulp chamber (endo-preparation). Computer-generated ceramic corono-radicular restorations (Cerec endo-crowns) were bonded to these preparations. The purpose of this study was to evaluate the survival rate and the clinical quality of CAD/ClM endo-crowns after 2 years. Materials and Methods: 19 Cerec endo-crowns (4 premolars and 15 molars] in 13 patients were examined using modified USPHS criteria at baseline and after an average time of 26 months. The ratings of the two examinations were compared. Results: The service time of the 19 endo-crowns was 14 to 35.5 (x± SD: 26±6) months. One molar endo-crown failed after 28 months because of recurrent caries. Conclusion: The overall clinical quality of the Cerec endo-crowns was very good, and so far, the clinical concept appears feasible.