Purpose: To evaluate the effects of acidic functional monomers on the bond strength and durability of an acrylic resin joined to Ti-6Al-7Nb alloy and component metals. Materials and Methods: Disk specimens of two different sizes (10 and 8 mm in diameter and 2.5 mm in thickness) were prepared from uncast Ti-6Al-7Nb alloy, titanium, aluminum, and niobium. The specimens were ground with abrasive paper and divided into 8 groups: unprimed control, primed with Acryl Bond, Alloy Primer, All Bond II Primer B, Estenia Opaque Primer, M.L. Primer, MR. Bond, and Super-Bond Liquid. The disks were bonded with tri-n-butylborane (TBB)-initiated acrylic resin, and shear bond strengths were determined both before and after thermocycling. Results: The Alloy Primer and Estenia Opaque Primer agents, which contain a hydrophobic phosphate monomer (MDP), and Super-Bond Liquid demonstrated a durable bond with Ti-6Al-7Nb alloy. MDP was also effective in bonding Ti, Al, and Nb. Conclusion: The two primers containing MDP were effective for treating Ti-6Al-7Nb alloy and Ti. Al and Nb showed bonding behavior similar to Ti-6Al-7Nb alloy and Ti when the two metals were treated with acidic primers and bonded with the TBB-initiated acrylic resin. Keywords: niobium, phosphate, Ti-6Al-7Nb alloy, titanium