Purpose: This article presents a new treatment protocol in maxillofacial prosthodontics. Materials and Methods: A case report of a patient suffering from an orbital defect after tumor resection is presented. To explain the treatment protocol, the procedure of fabricating an implant-retained orbital prosthesis for this patient is discussed. Results: After tumor resection, implants were placed and a prosthesis was made based on both a CT scan and computer-supported technology. Conclusion: The integration of several existing techniques in and outside the field of maxillofacial prosthodontics led to a treatment protocol that was shown to be beneficial in the presented case and others. Int J Prosthodont 2003;16:326–328.