Purpose: The purpose of this study was to investigate and compare the precision of fabrication in repeatedly produced computer numeric controlled (CNC)–milled frameworks with conventional castings, and to analyze the distortion from application of different veneering materials. Materials and Methods: Twenty identical titanium frameworks were fabricated by means of a CNC milling technique for the same master model. Five conventional frameworks were cast as a control group to the same model. The frames were measured with regard to fit in a coordinate measuring machine linked to a computer. Measurements were made during different stages of handling of the titanium framework, and after veneering materials had been applied. Results: The CNC frameworks showed a statistically better fit and precision of fabrication compared to conventional castings ( P< .05). The application of veneering material did not statistically affect the fit of the titanium frameworks ( P> .05). Conclusion: It is possible to fabricate implant-supported frameworks by means of the present CNC technique with a very high precision and repeatability. Int J Prosthodont 2003;16:194–200.