Thirty-two patients who had been treated with 71 computer-aided design/computer-assisted manufacture–fabricated Cercon crowns were followed to assess clinical performance by time-to-event analysis. Clinical examinations consisted of a complete dental and oral hygiene examination and a quality assessment by modified California Dental Association criteria. Four patients (6 crowns) were lost to follow-up; another 11 crowns had to be excluded from evaluation for comparability reasons. Six of 54 evaluated crowns experienced complications (PC = 11.1%) throughout a mean observation time of 21 months. Survival was estimated at 0.98 over 24 months. The good overall clinical performance was affected predominantly by technical complications of the veneering ceramic (PTC = 9.3%). Int J Prosthodont 2010;23:429–431.