Purpose: The aim of this study was to evaluate the interfacial bond strength between different types of silicone facial elastomers and denture resins. Materials and Methods: The facial materials studied were Cosmesil and Ideal, whereas SR 3/60, SR 3/60 Quick, and Triad were included in the denture resins group. The “overlap-joint” model was used to evaluate the bond strength, and the samples were placed in tension until failure. The bonding surfaces were treated with a primer. Ten samples for each silicone/resin group were tested. The results were subjected to two-way analysis of variance and Tukey’s test for comparison. Results: The bond strength was affected by the type of silicone elastomer and denture resin. An interaction between them was also noted. The bond strength ranged from 0.03 to 0.23 MPa. Conclusion: Cosmesil condensation-type silicone always showed higher bond strength with the three different types of denture resins compared to Ideal addition silicone, keeping other variables associated with the silicone-resin bond fixed.