Purpose: There have been numerous attempts to improve the mechanical properties of acrylic resin. However, the fracture of dentures is still an unresolved problem. The potential advantage of self-reinforcement should be improved mechanical properties over the amorphous random polymer. This study investigated the addition of poly(methyl methacrylate) (PMMA) beads in a variety of percentages on a range of mechanical properties of PMMA denture base acrylic resin. Materials and Methods: The transverse and impact strengths and hardness of acrylic resin specimens stored in water for periods of 1 week and 6 months prior to testing were investigated. Results: The results showed that for specimens stored for 1 week, the addition of up to 25% beads produced a significant increase in the modulus of elasticity. Addition of 5% beads produced a slight but nonsignificant increase in the modulus of rupture, although additions of increasing percentages produced a decrease in the modulus of rupture. The impact strength was increased for 5% to 25% beads and decreased for 40% beads. The hardness showed only small changes. For specimens stored in water for 6 months, the modulus of rupture decreased with increasing percentages of beads. The addition of beads up to 10% significantly increased the modulus of elasticity. There was no significant increase in impact strength but a significant increase in hardness for 5% beads. Conclusion: The addition of PMMA beads to acrylic resin did not produce a substantial improvement in the mechanical properties and cannot be recommended as a method of reinforcement in its present form.