Purpose: The purpose of this study was to describe a new application of craniofacial implants, as anchoring elements for wigs. Materials and Methods: In two patients, a split-skin graft was used to close a soft tissue defect in the occipital, parietal, temporal, and frontal region (defect size of 10 cm 3 33 cm and 10 cm 3 14 cm). Six titanium implants were placed in each patient. Six months after implant placement, abutment connection was performed and titanium magnets were adapted. Subsequently, an implant-retained wig was constructed. Results: In a follow-up period of between 10 and 22 months no implant failed. The incorporated wigs effectively retain a functionally and cosmetically successful craniofacial rehabilitation. Conclusion: Despite these successful treatments, further research is needed before craniofacial implants as anchoring elements for wigs can be considered a standard option in the rehabilitation of craniofacial alopecic defects.