Purpose: This study evaluated stress distribution in metal frameworks constructed on implants under masticatory forces using computer simulations. Materials and Methods: Three-dimensional finite element analysis was used to study four different veneering materials–metal framework combinations using Calcitek implants. The veneering materials used in the study were porcelain, heat-polymerized poly(methyl methacrylate) resin, microfilled composite resin, and glass-modified composite resin. All computations were conducted for different levels on the buccal and lingual sides. Results: Changing the veneering material on the prosthesis produced significant effects on stress levels and stress distribution on the metal frameworks. Stresses were concentrated along the marginal area of the prosthesis. Acrylic resin showed greater displacement than porcelain, probably because of its lower modulus of elasticity. Conclusion: In comparison to porcelain, more stress is borne by the acrylic resin–veneered metal framework under static loading.