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Volume 18 , Issue 5
September/October 2005

Pages 377382

Increased Antibacterial Activity of Zinc Polycarboxylate Cement by the Addition of Chlorhexidine Gluconate in Fixed Prosthodontics

Berrin Ors Orug, DDS, PhD/Mehmet Baysallar, MD, PhD/Deniz Cetiner, DDS, PhD/Ayten Kucukkaraaslan, PhD/Berna Dogan, DDS, PhD/Levent Doganci, MD, PhD/Eralp Akca, DDS, PhD/Belgin Bal, DDS, PhD

PMID: 16220801

Purpose: This study evaluated the antibacterial activity of water-activated zinc polycarboxylate cement with adjunctive 0.12% chlorhexidine gluconate on the subgingival microbiota in fixed partial dentures. Materials and Methods: Thirty-six teeth prepared as fixed partial denture abutments in 9 patients were cemented randomly using water-activated zinc polycarboxylate cement (control group) or water-activated zinc polycarboxylate cement, including 0.12% chlorhexidine gluconate (test group). A total of 108 subgingival plaque samples were analyzed at baseline, immediately before permanent cementation (5 weeks), and 8 weeks later (at 13 weeks). Results: In the control group, the subgingival microbiota altered to closely resemble the flora of chronic gingivitis (increased proportions of gram-negative anaerobes such as Prevotella intermedia, Fusobacterium nucleatum) by 13 weeks. In contrast, the microflora at test sites comprised predominantly gram-positive facultative cocci and rods at 13 weeks. Conclusion: This study demonstrated that the addition of 0.12% chlorhexidine gluconate may enhance the antimicrobial action of polycarboxylate cements to ensure the maintenance of a microflora compatible with periodontal health, at least up to 13 weeks post-cementation. Int J Prosthodont 2005;18:377382.

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