Purpose: This study investigated the effect of different cements on microleakage and marginal adaptation of porcelain crowns. Materials and Methods: Eighty extracted molars were divided into two groups. Teeth in one group were prepared to receive Procera AllCeram crowns, whereas the other group was prepared to receive metal-ceramic crowns. Copings were made following standard techniques, and groups were divided for cementation with zinc phosphate, glass-ionomer, resin-modified glass-ionomer, or resin cement. Specimens were subjected to thermocycling prior to microleakage testing, then sectioned. Microleakage was scored using a five-point scale; marginal adaptation was assessed with a traveling microscope. Results: A significant association was found between cement type and degree of microleakage. With zinc phosphate, 76% of Procera AllCeram and 90% of metal-ceramic copings exhibited extensive microleakage. With glass-ionomer, 49% of Procera AllCeram and 66% of metal-ceramic copings had 0 microleakage scores; with resin-modified glass-ionomer, 10% of Procera AllCeram and 84% of metal-ceramic copings had 0 microleakage scores. With resin cement, 34% of Procera AllCeram and 96% of metal-ceramic copings exhibited 0 microleakage. Procera AllCeram copings had a significantly larger mean marginal gap (54 µm) compared to metal ceramic (29 µm). Conclusion: In both types of crowns, the use of resin cement resulted in the highest percentage of 0 microleakage scores, whereas the zinc phosphate cement resulted in the highest percentage of extensive microleakage.