Purpose: The clinical performance of three- and four-unit fixed partial dentures (FPDs) with frameworks made of yttria partially stabilized zirconia was determined after a mean observational period of 84 months. Materials and Methods: Seventy-five patients were treated with 99 posterior FPDs. Fifty-one specimens were veneered with an experimental ceramic suitable for titanium and zirconia frameworks; 48 restorations were veneered with a commercially available low-fusing ceramic optimized for zirconia frameworks. All restorations were luted with zinc-phosphate cement. Statistical analysis was performed according to Kaplan-Meier; potential risk factors were analyzed using the Cox regression analysis. Results: Nineteen restorations failed completely: 12 due to technical complications, 6 due to biologic complications, and 1 for unknown reasons. The overall survival rate after 84 months was 83.4%. Thirty-two events required clinical intervention for restoration maintenance, resulting in a time-dependent success rate of 57.9% after 84 months. Nineteen dropouts occurred during the follow-up time. None of the evaluated factors showed an association with survival or success of the restorations. Conclusions: After a mean observational period of 7 years, the survival and success rates of zirconia-based posterior FPDs were inferior to those published for metalceramic FPDs. The majority of failures were caused by technical complications (material fractures). The main reasons for clinical intervention to maintain function were fractures of the veneering ceramic and decementations. Int J Prosthodont 2013;26:164–171. doi: 10.11607/ijp.3229