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ENDO - Endodontic Practice Today

Edited by Bun San Chong and Edgar Schäfer

Official Publication of the Belgian Association for Endodontology and Traumatology (BAET) and the French Society of Endodontics (SFE)

ISSN (print) 1753-2809 • ISSN (online) 1753-2817


Spring 2014
Volume 8 , Issue 1

Pages: 57-62
Share Abstract:

Evaluation of cytotoxicity and physicochemical properties of silicone-based endodontic sealer GuttaFlow 2

Silva, Emmanuel J.N.L. / Herrera, Daniel R. / Rosa, Tiago P. / Duque, Thais M. / Gomes, Brenda P.F.A. / Zaia, Alexandre A.

Introduction: The aim of the study was to evaluate the cytotoxicity, radiopacity, pH, flow and solubility of a silicone-based and an epoxy resin-based endodontic sealer: GuttaFlow 2 and AH Plus, respectively.
Methods: Cytotoxicity, radiopacity and flow evaluation were performed following ISO requirements. pH was measured at periods of 3, 24, 72, 168 h. Cytotoxicity was evaluated by MTT assay to check the Balb/c 3T3 cells viability at 1 to 3 week periods. Data were statistically analysed by ANOVA and Tukey test with a significance level of 5%.
Results: GuttaFlow 2 was non-cytotoxic in all tested periods. AH Plus was more cytotoxic than GuttaFlow 2 when freshly mixed and after 1 week (P < 0.05). After 2 weeks, AH Plus becomes noncytotoxic. Although AH Plus presented higher radiopacity than GuttaFlow 2 (P < 0.05), both sealers showed minimum required values. GuttaFlow 2 and AH Plus presented a pH level close to neutral in all tested times. AH Plus also showed significantly lower flow than that of GuttaFlow 2 (P < 0.05). Both sealers showed values complying with the solubility minimum requirements.
Conclusion: GuttaFlow 2 demonstrated suitable biological and physicochemical properties for an endodontic sealer.

Keywords: AH Plus, cytotoxicity, GuttaFlow 2, physicochemical properties, root canal sealer

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